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March 25, 1996

Severe Hyponatremia During Therapy With Fluoxetine

Author Affiliations

From the Department of Internal Medicine, Red Cross Hospital, Beverwijk, the Netherlands (Drs ten Holt and Schrijver); and Department of Internal Medicine, Eemland Hospital, Amersfoort, the Netherlands (Drs van Iperen and Bartelink).

Arch Intern Med. 1996;156(6):681-682. doi:10.1001/archinte.1996.00440060111014

We described two elderly patients with severe hyponatremia that was probably caused by inappropriate secretion of antidiuretic hormone. The hyponatremia arose during fluoxetine (Prozac) antidepressant therapy.

(Arch Intern Med. 1996;156:681-682)