[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.145.176.252. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
October 28, 1996

Exercise-Associated Amenorrhea, Low Bone Density, and Estrogen Replacement Therapy

Author Affiliations

From the Department of Obstetrics and Gynaecology, University of Alberta, Edmonton.

Arch Intern Med. 1996;156(19):2193-2195. doi:10.1001/archinte.1996.00440180051005
Abstract

Background:  Women with exercise-associated amenorrhea have a higher frequency of osteoporosis than eumenorrheic runners and sedentary women. The use of hormone replacement therapy was suggested many years ago to increase bone density in exercising women with amenorrhea and low bone density.

Objective:  To determine if hormone replacement therapy increased bone density in women with exercise-associated amenorrhea.

Methods:  We performed a retrospective clinical study comparing the changes in bone density in 8 women runners who took hormone replacement therapy with 5 who refused medication but who were followed up as controls over 24 to 30 months.

Results:  Vertebral and femoral neck bone density significantly increased by 8.0%±1.2% (±SEM) and 4.1%±0.3% (±SEM), respectively, in 8 women runners with amenorrhea taking 24 to 30 months of estrogen replacement therapy with progestational support. Control women not taking replacement therapy had nonsignificant decreases of less than 2.5% at each site.

Conclusion:  Hormone replacement therapy appears to increase bone density in amenorrheic runners.Arch Intern Med. 1996;156:2193-2195

×