I enjoyed the extensive review article on restless legs syndrome by O'Keeffe,1 which appeared in the February 12, 1996, issue of the Archives. The background and what is known of this syndrome is nicely covered. However, it seems to me that the question of the pathogenesis of the syndrome is still up in the air.
For what it is worth, I offer the following observation on myself: beginning approximately 20 years ago, at the age of 60 years, some stasis started to occur in the lower part of my legs at the end of a long day. This was especially pronounced if I had been on my feet more than usual. I have developed the habit of reading in bed with my feet elevated before going to sleep. My reading would sometimes involve a period of an hour or longer. During this time, the edema would rather rapidly subside,
McMahon JM. A Serendipitous Observation Regarding Restless Legs Syndrome. Arch Intern Med. 1996;156(20):2386-2390. doi:10.1001/archinte.1996.00440190144017