Myasthenia gravis is a disease of the neuromuscular junction in which normal transmission of the neuron-to-muscle impulse is impaired or prevented by acetylcholine receptor antibodies. Several classes of drugs have been associated with clinical worsening of existing myasthenia gravis, and a small subset of drugs, most notably the antirheumatic agent penicillamine, have been implicated in the pathogenesis of a variant of the disease. Recent case reports and other documented evidence link a number of specific agents with clinical worsening of myasthenia gravis.
Arch Intern Med. 1997;157:399-408
Wittbrodt ET. Drugs and Myasthenia GravisAn Update. Arch Intern Med. 1997;157(4):399-408. doi:10.1001/archinte.1997.00440250045006