Prader-Willi syndrome is a disorder characterized by obesity, hypogonadism, hypotonia, and mental retardation, which is genetically caused by a deletion of a small part of chromosome 15 in some, but not all, patients.1-4 Obesity is associated with diabetes mellitus of the maturity-onset type. The hyperphagia associated with Prader-Willi syndrome is severe and chronic and is responsible for the early mortality of people with the condition. The hyperphagia, together with the behavioral difficulties, makes Prader-Willi syndrome one of the most serious and pervasive conditions with respect to its impact on the family unit.
Report of a Case.
We treated a male patient with Prader-Willi syndrome and overt diabetes mellitus for which he took insulin; we found that the addition of a small dose of mazindol to the insulin therapy was effective in preventing hyperglycemic coma. At the time of the initial mazindol administration, the patient was 23 years old and
Inui A, Uemoto M, Takamiya S, Shibuya Y, Baba S, Kasuga M. A Case of Prader-Willi Syndrome With Long-term Mazindol Treatment. Arch Intern Med. 1997;157(4):464. doi:10.1001/archinte.1997.00440250124020