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October 13, 1997

Idiopathic Calcitriol-Induced HypercalcemiaA New Disease Entity?

Author Affiliations

From the Division of Internal Medicine, Kaplan Hospital, Rehovot, Israel.

Arch Intern Med. 1997;157(18):2142-2145. doi:10.1001/archinte.1997.00440390144017

W describe 3 patients with a prolonged history of hypercalcemia. The patients did not take any vitamin supplements. All patients had low parathyroid hormone (PTH), high calcitriol (1,25(OH)2D3), and high angiotensin-converting enzyme (ACE) blood levels. There was no evidence of sarcoidosis or any other underlying disease in the results of an extensive workup. Treatment with prednisone resulted in normalization of calcium levels in all patients. They remained dependent on low-dose prednisone on a subsequent prolonged follow-up.