Copyright 2005 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2005
The overenrollment in our trial1 resulted from an unanticipated jump in patient randomization at several large research centers, just as we were nearing the 200-patient mark. Using the day we accrued the 200th patient as a cutoff, we have now identified the first 209 randomized patients. Analysis of their data confirmed the superiority of Pennsaid (a topical 1.5% [wt/wt] diclofenac sodium solution in a carrier containing dimethyl sulfoxide [Dimethaid Health Care Ltd, Markham, Ontario]) (pain, P<.001; physical function, P<.001; patient global assessment, P = .002; mean difference between groups for pain, 2.3).
Roth SH, Shainhouse JZ. Efficacy and Relevance of Topical Diclofenac for Osteoarthritic Pain—Reply. Arch Intern Med. 2005;165(5):589-590. doi:10.1001/archinte.165.5.589