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Editor's Correspondence
March 14, 2005

Efficacy and Relevance of Topical Diclofenac for Osteoarthritic Pain—Reply

Author Affiliations

Copyright 2005 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2005

Arch Intern Med. 2005;165(5):589-590. doi:10.1001/archinte.165.5.589

In reply

The overenrollment in our trial1 resulted from an unanticipated jump in patient randomization at several large research centers, just as we were nearing the 200-patient mark. Using the day we accrued the 200th patient as a cutoff, we have now identified the first 209 randomized patients. Analysis of their data confirmed the superiority of Pennsaid (a topical 1.5% [wt/wt] diclofenac sodium solution in a carrier containing dimethyl sulfoxide [Dimethaid Health Care Ltd, Markham, Ontario]) (pain, P<.001; physical function, P<.001; patient global assessment, P = .002; mean difference between groups for pain, 2.3).

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