Memory disturbances are one of the first clinical signs detected in patients with Alzheimer disease (AD). The control of protein translation, including the kinases mTOR (mammalian target of rapamycin) and p70S6k, participates in explicit memory formation. Peripheral lymphocytes have impaired metabolism in AD.1 Our group recently reported a significant decrease of activated p70S6k expression in lymphocytes of patients with AD compared with control individuals.2 We report herein a significant correlation between activated p70S6k expression and long-term and working memory and language alterations.
Paccalin M, Pain-Barc S, Pluchon C, Paul C, Bazin H, Gil R, Hugon J. The Relation Between p70S6k Expression in Lymphocytes and the Decline of Cognitive Test Scores in Patients With Alzheimer Disease. Arch Intern Med. 2005;165(20):2428-2429. doi:10.1001/archinte.165.20.2428