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Comments, Opinions, and Brief Case Reports
January 8, 2001

Lymphoid Interstitial Pneumonitis in Patients With the Human Immunodeficiency Virus: Usefulness of Alveolar Lymphocytes Gene by Polymerase Chain Reaction

Arch Intern Med. 2001;161(1):124. doi:

In adult patients with the human immunodeficiency virus (HIV), lymphoid interstitial pneumonitis (LIP) is part of a diffuse CD8-infiltrative lymphocytosis syndrome.1 Lung biopsy is the criterion-standard to diagnose LIP.2 Lymphoid interstitial pneumonitis is characterized by a histologic pattern of diffuse infiltration with predominantly small lymphocytes and plasma cells in the alveolar septa and along the lymphatic vessels. In a recent study, gene rearrangement analysis of alveolar lymphocytes by polymerase chain reaction (PCR) seemed to be sensitive enough for the diagnosis of B-cell pulmonary non-Hodgkin lymphoma in immunocompetent patients.3

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