Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001
The concept of evidence-based medicine is as simple as it is compelling and has indisputably had a major influence on modern therapeutics. Evidence-based medicine aims to objectively evaluate all medical interventions with a view of translating this knowledge into routine medical practice and thus enhancing patient care. One of its most powerful tools to achieve this aim is the systematic review (SR).1 Systematic reviews, including meta-analyses, aim at impartially assessing the evidence for a given treatment and usually focus on efficacy or effectiveness. Yet safety data are equally important for evidence-based decisions about the value (or otherwise) of therapeutic interventions.
Ernst E, Pittler MH. Systematic Reviews Neglect Safety Issues. Arch Intern Med. 2001;161(1):125-126. doi: