We read with interest the recent article by Carson et al1 on immune function and vaccine responses in healthy elderly subjects. Given the increasing proportion of people older than 65 years and the importance of influenza vaccination for the prevention of morbidity and mortality in this population, improved understanding of age-related functional changes of the immune response is important. However, as a result of a number of methodologic issues, we believe that the conclusions made by Dr Carson and colleagues need to be cautiously interpreted.
Hamer DH, Meydani SN. Immune Function in the Elderly. Arch Intern Med. 2001;161(3):482. doi: