In March 1995, a 67-year-old woman came to the outpatient clinic because her body weight had increased from 48 to 55 kg during 1 year. On physical examination, she was neither cushingoid nor hypertensive. Her morning plasma corticotropin level was 19 pmol/L (reference range, 1-12 pmol/L). One milligram of dexamethasone completely suppressed plasma corticotropin and cortisol levels. The corticotropin and cortisol values remained between 6 and 9 pmol/L and 323 and 400 nmol/L, respectively, after 3 years.
Takao T, Mimoto T, Yamamoto M, Hashimoto K. Preclinical Cushing Disease. Arch Intern Med. 2001;161(6):892-893. doi: