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Comments, Opinions, and Brief Case Reports
April 9, 2001

Cavernous Sinus Syndrome Due to Vaccination-Induced Giant Cell Arteritis

Arch Intern Med. 2001;161(7):1008-1009. doi:

We read with interest the report of Perez et al1 about a woman who developed giant cell arteritis (GCA) after vaccination against influenza. In contrast to their statement that GCA due to vaccination against influenza has not been described before, we want to point out that Ghose et al2 suggested such a pathomechanism in 1976. Ghose and colleagues described 4 women with GCA, 1 of whom was vaccinated against influenza shortly before the onset of symptoms. The initial finding in this woman was fever. Later, she developed headache, jaw pain, chills, aching muscles, abdominal pain, intermittent blurring of vision, swelling of the left eye, and swelling of the left-sided nuchal glands. Tender temporal arteries and polymyalgia rheumatica were entirely absent in this woman. However, she had an increased blood sedimentation rate and anemia, and her temporal artery biopsy specimen showed the typical features of GCA. In another case, one that was reported by Petersdorf and Beeson3 in 1961, typical clinical and laboratory features of GCA followed immediately after the administration of typhoid vaccine.

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