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Comments, Opinions, and Brief Case Reports
April 23, 2001

Diabetes Insipidus Due to Streptococcus pneumoniae Meningitis

Arch Intern Med. 2001;161(8):1114-1115. doi:

Diabetes insipidus (DI), which is characterized by polyuria and polydipsia due to excessive urinary loss of solute-free water, can be either central (CDI) or nephrogenic.1 In CDI, plasma levels of arginine vasopressin do not increase in response to a rise in plasma osmolarity. A number of intracranial conditions, such as neoplastic or infiltrative lesions of the hypothalamus or pituitary gland, severe head injuries, neurosurgery, and central nervous system infection, can cause CDI.1 Central DI has been reported as a complication of bacterial meningitis, but most of the cases have occurred in children.2 We describe a 45-year-old man with human immunodeficiency virus (HIV) infection and Streptococcus pneumoniae meningitis who developed central diabetes insipidus, most likely as a complication of raised intracranial pressure.

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