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Comments, Opinions, and Brief Case Reports
May 14, 2001

Bleeding Associated With Doxycycline and Warfarin Treatment

Arch Intern Med. 2001;161(9):1231. doi:10.1001/archinte.161.9.1231

Select anti-infective agents such as co-trimoxazole, metronidazole, select quinolones, macrolides, azole antifungal agents, and isoniazid have been associated with prolonged international normalized ratio and/or bleeding.1 Few cases have been reported between doxycycline and warfarin.2,3 We report a case of possible retroperitoneal bleeding associated when these 2 drugs were administered concurrently.

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