Because influenza vaccines are not fully protective against influenza A and B, immediate treatment with neuraminidase inhibitors could further reduce the annual morbidity and mortality associated with influenza (notably in the presence of high-risk conditions). As described by Monto et al,1 more studies are needed on early recognition of influenza infection on the basis of demographics, comorbidity, and signs and symptoms. We believe, however, that owing to the selection of the study subjects and incomplete statistical analysis performed by Monto et al, their study results are of little value to practicing physicians.
Hak E, Moons KGM, Verheij TJM, Hoes AW. Clinical Signs and Symptoms Predicting Influenza Infection. Arch Intern Med. 2001;161(10):1351. doi: