Severe blood coagulation disorders are rare complications during primary cytomegalovirus (CMV) infection. We describe 2 patients who were receiving azathioprine treatment when they developed blood coagulation disorders (thrombotic microangiopathy in one patient and disseminated intravascular coagulation in the other) during primary CMV infection. We discuss herein the mechanisms underlying these complications in CMV disease and emphasize the importance of a prompt diagnosis for rapid and specific treatment, especially in immunocompromised patients.
Humblot S, Martin T, Pasquali J, Korganow A. Blood Coagulation Disorders During Primary Cytomegalovirus Infection. Arch Intern Med. 2001;161(17):2149-2150. doi: