Fluoroquinolones are widely used in the treatment of community-acquired urinary and respiratory tract infections. While the safety profile of these agents is established, neurotoxicity has been associated with ciprofloxacin, ofloxacin, pefloxacin, norfloxacin, and alatrofloxacin.1,2 Reported below is the case of an elderly woman who developed myoclonus and generalized seizures while receiving gatifloxacin therapy for a urinary tract infection.
Marinella MA. Myoclonus and Generalized Seizures Associated With Gatifloxacin Treatment. Arch Intern Med. 2001;161(18):2261–2262. doi: