November 12, 2001

Genetic Testing and Medical Decision Making

Author Affiliations

Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Intern Med. 2001;161(20):2406-2408. doi:10.1001/archinte.161.20.2406

AS ILLUSTRATED in this issue of the ARCHIVES, genetic testing is an increasingly informative tool in the diagnosis, prevention, and treatment of disease. The usefulness of this tool, however, hinges on its transparency in the clinical setting. Results of research17 indicate that clinicians will experience predictable difficulties in interpreting probabilities associated with genetic testing, indeed with testing generally. These difficulties can be avoided by following the guidelines herein. With respect to these difficulties, genetic testing can be divided into 2 phases corresponding to the following questions: (1) Who should be tested? and (2) How should the test result be interpreted?

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