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Editor's Correspondence
November 26, 2001

Epidemiologic Evidence Existing for Calcium Antagonists—Reply

Arch Intern Med. 2001;161(21):2627-2628. doi:

In reply

We appreciate the comments by Dr Zuccala and colleagues regarding our review of calcium channel blockers (CCBs)1 and their further clarification of their study's findings. As Dr Zuccala et al point out, their observational study evaluated hemoglobin level decrease (≥ 12 g/dL) rather than "major hemorrhage."2 We did try to depict this for their study in Table 7 by noting it in the "Bleeding End Point" column, but we certainly appreciate their emphasis on the study's focus. Although the section's heading of "Links to Major Hemorrhage" may not be, strictly speaking, entirely accurate, the majority of articles discussed in our review do center on clinically important bleeding.1

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