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Editor's Correspondence
November 26, 2001

Is Hyperhomocysteinemia a Risk Factor or a Consequence of Coronary Heart Disease?

Arch Intern Med. 2001;161(21):2628. doi:

The question of whether moderately high serum or plasma levels of total homocysteine are a risk factor for coronary heart disease (CHD) and other atherothrombotic disorders has long been debated and is still unclear. The uncertainty mainly stems from the discrepant results obtained in case-control and prospective cohort studies. While case-control study results consistently showed a positive association between hyperhomocysteinemia and atherothrombotic events, prospective cohort studies gave conflicting results.1

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