Dr Ruiz-Garcia et al raise several issues pertaining to our recently published article.1 First, they point out that diastolic blood pressure reductions in women and blood pressure reductions in persons aged 70 and older did not reach statistical significance. The comparatively low baseline intake of sodium in women (<130 mEq/24 h) might explain the reduced effect size; still, it is noteworthy that systolic blood pressure reductions in this subgroup were statistically significant. In persons 70 and older, the most likely explanation for the nonsignificant effect size is inadequate study power. This subgroup (n = 132) was the smallest of the subgroups examined in our article.
Appel LJ. Is Salt So Harmful for Hypertension in Our Elderly?—Reply. Arch Intern Med. 2001;161(21):2632-2633. doi: