September 1958

Periodic Neutropenia

AMA Arch Intern Med. 1958;102(3):462-467. doi:10.1001/archinte.1958.00030010462019

Periodic or cyclic neutropenia is considered to be a rare hematological disorder, characterized by a chronic rhythmic recurrence of severe neutropenia or agranulocytosis at approximately three-week intervals. Ordinarily the worst phase of the neutropenia extends for five to eight days, and this may be associated with a compensatory rise in the monocytes or eosinophils, particularly if there is a normal number of leukocytes present.1 During this same period serial bone marrow studies have been reported by some observers to show a complete suppression of the granulocytic series, from the myeloblast to the mature neutrophil1-5; others have noted only a maturation arrest at the promyelocyte level, a result probably due to the lack of serial aspirations.6-9 During the normal or relatively normal intervals between the episodes of severe neutropenia, the bone marrow is normal. On two occasions there have been abnormal concentrations of platelets associated with this disease; one author10 reported