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September 1958

Addison's Disease and Diabetes Insipidus

AMA Arch Intern Med. 1958;102(3):478-483. doi:10.1001/archinte.1958.00030010478021

The metastatic involvement of both adrenal glands with complete replacement by neoplasm, resulting in Addison's disease, is recognized as a most unusual if not rare occurrence.1-6 The first well-documented cases in the American literature were reported by Butterly and his associates,1 in 1952; Wallach and Scharfman,2 in 1952, and Sahagian-Edwards and Holland,3 in 1954. In 1957, Leary and Masters5 also reported a case of Addison's disease produced by metastasis from gastric carcinoma.

Metastatic carcinoma to the pituitary gland involving both the anterior and posterior lobes and the hypothalamus, resulting in diabetes insipidus, is exceedingly rare.6-8

The survival of a patient 10 years after pneumonectomy for primary bronchogenic carcinoma, although not infrequently reported, remains an unusual occurrence.10-14 In personal communications Watson11 stated he had four cases of 10-year survival, and in one of them a second primary lung cancer developed which was nonresectable. Overholt13 reported a five-year cure rate of 19%