Original Articles
November 1968

Aldosterone Production After Suppression of Corticotropic Secretory Activity

Arch Intern Med. 1968;122(5):394-398. doi:10.1001/archinte.1968.00040010394003

The effect of suppressive doses of glucocorticoids on aldosterone secretion was studied. Dexamethasone in a dose of 2 mg/day for two days resulted in a 38% decrease in aldosterone secretory rate (ASR) in 18 of 22 patients studied. Three of the four patients who showed no decrease in ASR had primary aldosteronism. Angiotensin infusion increased ASR before and after dexamethasone suppression, but the rise in ASR after combined dexamethasone suppression and angiotensin infusion was still 30% less than the control-unstimulated ASR. Sensitivity to endogenously generated angiotensin was similarly blunted by dexamethasone suppression. It is concluded that suppression of endogenous adrenocorticotropic activity significantly reduces the adrenal secretory response to angiotensin.