Relatively few cases of gonococcus arthritis and periostitis treated by the subcutaneous injection of dead gonococci have so far been recorded. Cole and Meakins1 reported fifteen cases of gonococcus arthritis in which inoculations were given and systematic observations made on the opsonic index. After a careful study of the cases they concluded that inoculation of dead gonococci appeared to have a decided value in favorably influencing the course of the disease.
This paper is based on the study of forty cases of gonococcus infection, including thirty-one cases of arthritis.2 The diagnosis of each case included in the series was determined beyond any reasonable doubt, from the clinical history and course as well as from the associated genital infection. In all the cases in any way obscure the diagnosis was confirmed by the isolation of the gonococcus from the joints, and in two cases from the
IRONS EE. THE TREATMENT OF GONOCOCCUS ARTHRITIS BY INJECTIONS OF DEAD GONOCOCCI, AND THE CLINICAL REACTION WHICH FOLLOWS THE INJECTIONS.. Arch Intern Med (Chic). 1908;I(IV):433-441. doi:10.1001/archinte.1908.00050030105005