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September 1909

EFFECTS OF THE ADMINISTRATION OR THE WITHHOLDING OF IODIN-CONTAINING COMPOUNDS IN NORMAL, COLLOID OR ACTIVELY HYPERPLASTIC (PARENCHYMATOUS) THYROIDS OF DOGSSOME EXPERIMENTS ON (CONGENITAL) PRENATAL THYROID HYPERPLASIA IN DOGS; REMARKS ON THE CLINICAL MANIFESTATIONS ASSOCIATED WITH MARKED THYROID HYPERPLASIA

Author Affiliations

CLEVELAND, OHIO

From the Laboratories of Experimental Medicine and Pharmacology of Western Reserve University.

Arch Intern Med (Chic). 1909;IV(3):253-270. doi:10.1001/archinte.1909.00050190062005
Abstract

The observations and experiments here recorded have been made on dogs, and include three with normal, eight with colloid and seventeen with actively hyperplastic glands, as ascertained by the first specimen of thyroid removed. The plan followed has been to remove a control portion of the thyroid from each dog for histologic diagnosis and iodin determination, and at intervals to remove other portions for comparison.

Our experiments may be divided into two groups: (1) those in which iodin was administered and (2) those in which no iodin was administered, except what was contained in a liberal diet of cooked meat, bread, sodium chlorid, milk and water. The food being the same in each group, no other remarks are necessary, except that dogs normally store some iodin from such a diet. These two groups have been tabulated, and in presenting Tables 1 and 2 we have arranged the cases according

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