Much experimental evidence has been advanced in the endeavor to determine the immediate cause or causes concerned in the death of animals whose kidneys have been removed or whose ureters have been ligated; and as the result of apparent differences in the duration of postoperative life, attempts have been made to ascribe to the kidney a function other than that of excretion in the general sense. That the simple ligation of the ureter resulted in the stoppage of urine formation but did not interfere with the production of an internal secretion, presumably necessary to the life of the animal, seemed a logical conclusion from the notion that animals lived longer with their ureters ligated than when both kidneys were extirpated. These statements find considerable support from clinical findings in cases in which both ureters were accidentally ligated or in which a persistent anuria existed.
Recent experimental work does
JACKSON HC, SAIKI T. A STUDY OF THE BLOOD AND FECES BEFORE AND AFTER BILATERAL NEPHRECTOMY AND DOUBLE URETERAL LIGATION, AND OF THE URINE SECRETED AFTER REIMPLANTATION OF THE URETERS. Arch Intern Med (Chic). 1912;IX(1):79-98. doi:10.1001/archinte.1912.00060130084006