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Article
January 1912

THE DETERMINATION OF INDIVIDUAL DOSAGE IN TUBERCULIN THERAPY

Author Affiliations

PITTSBURGH

Arch Intern Med (Chic). 1912;IX(1):114-127. doi:10.1001/archinte.1912.00060130119009
Abstract

A year ago we published a report of a year's study on a method to obtain a uniform reaction to tuberculin in patients of widely different character, both as regards extent of disease and physical condition.1 The method outlined in this and previous papers was an effort to obtain a specific, individual, biological test of the therapeutic doses of tuberculin, which would give uniform results in patients requiring this form of treatment. The basis of this method was laid in the varying sensitiveness to tuberculin, which was found by numerous observers to exist in the surface cells of individuals suffering from tuberculosis. We felt that such a method, if it could be evolved, would at least get rid of the tedious method formerly in vogue of starting all patients on an exceedingly small dose and gradually working up over a period of many months to a dose which

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