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February 1912

THE RÔLE OF ACIDOSIS OF THE TISSUES AS A FACTOR IN THE PRODUCTION OF AN ATTACK IN PAROXYSMAL HEMOGLOBINURIA

Author Affiliations

CINCINNATI

From the Laboratory of the Cincinnati Hospital, Medical Department, University of Cincinnati.

Arch Intern Med (Chic). 1912;IX(2):137-142. doi:10.1001/archinte.1912.00060140011002
Abstract

During January, 1910, a colored man suffering from paroxysmal hemoglobinuria was admitted to the Cincinnati Hospital. He gave a history of passing blood-colored urine, particularly on exposure to cold. While producing congestion above the elbow in order to obtain blood from the median vein for a Wassermann determination, it was noticed that at such times there was obtained a blood-serum which was laked. This led me to investigate more closely the effect of carbonic acid gas on the washed corpuscles obtained both from the patient and from a normal individual, and the effect of salts in controlling this hemolysis was also studied. This forms a complete report of the work done, and which was briefly referred to by Martin H. Fischer1 in his work on edema.

REPORT OF CASE 

History.  —The patient, H. C., colored, male, aged 26, single, entered the Cincinnati Hospital Dec. 31, 1909, suffering from pains

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