[Skip to Content]
[Skip to Content Landing]
Article
March 1912

THE PHTHALEIN TESTAN EXPERIMENTAL AND CLINICAL STUDY OF PHENOLSULPHONEPHTHALEIN IN RELATION TO RENAL FUNCTION IN HEALTH AND DISEASE

Author Affiliations

BALTIMORE

From the Pharmacological Laboratory of the Johns Hopkins University and the Genito-Urinary and Medical Clinics of the Johns Hopkins Hospital.

Arch Intern Med (Chic). 1912;IX(3):284-338. doi:10.1001/archinte.1912.00060150013002
Abstract

Phenolsulphonephthalein, which was first described by Remsen,1 is a bright red crystalline powder, somewhat soluble in water and alcohol and readily soluble in the presence of alkalies. The drug, as determined by Abel and Rowntree,2 is non-toxic, non-irritant locally, and is excreted practically entirely by the kidneys and with extraordinary rapidity, appearing in the urine normally within a few minutes of injection. In alkaline solution it presents a brilliant red color which is ideally adapted for quantitative colorimetric estimation.

TECHNIC  In our earliest work only the time of appearance, the time of maximum intensity of excretion, and the time of gross elimination were considered. In the course of the work it became evident that the color properties of this substance make it peculiarly well adapted for colorimetric methods of estimation, and for this purpose the Duboscq colorimeter was employed and has proved of the

First Page Preview View Large
First page PDF preview
First page PDF preview
×