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March 1912


Author Affiliations


From the Hunterian Laboratory of Experimental Pathology, Johns Hopkins Medical School.

Arch Intern Med (Chic). 1912;IX(3):365-399. doi:10.1001/archinte.1912.00060150094006

PART I. ABSENCE OF BLOOD COAGULATION IN A CASE OF SEPTICEMIA DUE TO THE PRESENCE OF ANTITHROMBIN.—A COMPARISON WITH "PEPTONE BLOOD"  Any one familiar with the literature on blood coagulation will realize that not all the factors entering into normal blood-clotting are clearly understood or are explained in various ways by different workers. Granting this uncertainty concerning the normal process of blood coagulation, it is not strange that there are more uncertainties and divergencies of opinion bearing on the factors concerned in abnormal or pathological coagulation of blood. It seems obvious that we cannot expect to have a satisfactory classification of various hemorrhagic diseases until we have a clear understanding of the mechanism of normal blood-coagulation. When this mechanism of coagulation is understood it will be possible to group together many of the indefinite groups of hemorrhagic diseases, hemophilias, purpuras, melenas, etc., according to whether there may

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