In 1891 Miller, in the preface to a series of articles1 entitled "The Human Mouth as a Focus of Infection," says:
During the last few years the conviction has grown continually stronger among physicians, as well as dentists, that the human mouth as a gathering-place and incubator of pathogenic germs performs a significant rôle in the production of varied disorders of the body, and that if many diseases whose origin is enveloped in mystery could be traced to their source, they would be found to have originated in the oral cavity.
Miller isolated fifty-eight varieties of microorganisms from the mouth, many of which are pathogenic or may under favorable circumstances become so.2 These findings were verified by Black, Vincentini and others.3
When it is realized that in some or all mouths there may be found at times bacteria of most infections, the importance of the study of
GILMER TL. CHRONIC ORAL INFECTIONS. Arch Intern Med (Chic). 1912;IX(4):499-504. doi:10.1001/archinte.1912.00060160102008