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May 1912

A FURTHER REPORT ON THE PRODUCTION OF EXPERIMENTAL CHRONIC NEPHRITIS IN ANIMALS BY THE ADMINISTRATION OF URANIUM NITRATE

Author Affiliations

(Toronto) SAN FRANCISCO

Arch Intern Med (Chic). 1912;IX(5):557-591. doi:10.1001/archinte.1912.00060170034003
Abstract

In a previous report1 I was able to show that by the administration of uranium nitrate to guinea-pigs it is possible to produce in them a condition which is analogous to various stages of chronic diffuse nephritis in man. These changes were quite constantly produced, and were found after the administration of uranium nitrate in any one of the following three ways: first, after a series of frequently repeated injections of very small doses of the drug; second, after a series of injections of moderately large doses at intervals of a considerable length of time; and third, after the injection of a single sublethal dose.

The earlier experiments were performed exclusively on guinea-pigs, but during the past three years a large number of experiments have been performed on guinea-pigs, rabbits and dogs in the hope of confirming my previous observations and of producing the condition among animals of

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