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June 1912

A CLINICAL AND HISTOLOGICAL STUDY OF A CASE OF PAGET'S DISEASE OF THE BONES WITH MULTIPLE SARCOMA FORMATION

Arch Intern Med (Chic). 1912;IX(6):641-656. doi:10.1001/archinte.1912.00060180003001
Abstract

PART I. BY L. S. FOSTER  Complete reports of bone changes of a rarefying nature, with marked evidence of overgrowth and deformity, corresponding exactly with the classic description of the disease known as osteitis deformans, are exceedingly rare.The late Sir James Paget, in his graphic, masterly and original study, was the first to isolate this type from the general group of bone diseases, claiming for it a clinical and a pathological recognition as a distinct, morbid process, and, in the Medico Chirurgical Transactions for the year 1877, gave the histories of five cases. Five years later he had gathered together twenty-three cases and outlined a clear and concise clinical picture, to which subsequent observers have made few additions of importance.``The disease is one beginning in advanced life, usually affecting many bones, most frequently the long bones of the lower extremity, the clavicle and the vault

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