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March 1910

THE EFFECT ON THE KIDNEYS OF TEMPORARY ANEMIA, ALONE AND ACCOMPANIED BY PERFUSION

Author Affiliations

PITTSBURGH, PA

From the Physiological Laboratories of Washington and Pittsburg Universities.

Arch Intern Med (Chic). 1910;V(3):232-245. doi:10.1001/archinte.1910.00050250017002
Abstract

INTRODUCTION  As set forth in a previous paper,1 investigations in this direction were suggested by the character of the results following transplantation of kidneys. To quote: "From the results on the kidneys, although my animals lived for several weeks, I came to the conclusion that permanent success was improbable owing to the latter factor" (i. e., injurious effect of the perfusion practiced). The results there reported have since been extended and confirmed, as shown below.2

METHOD  As previously described in the papers cited1,2 the method consists in temporarily shutting off the circulation in a segment of the aorta, including the origin of the renal arteries and then perfusing the kidneys by injecting the solution to be tested into this segment by means of a small trochar (or needle) thrust through the wall of the aorta (Fig. 1), the instrument being connected by means of a

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