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April 1910


Author Affiliations


From the Clinical Laboratory of the Sheppard and Enoch Pratt Hospital.

Arch Intern Med (Chic). 1910;V(4):374-381. doi:10.1001/archinte.1910.00050260051005

During the course of some studies of metabolism it was desired to bring about a moderate grade of anesthesia in order that a diagnostic lumbar puncture might be made possible, and for this purpose a mixture of scopolamin (hyoscin), hydrobromate and morphin (sulphate) was given subcutaneously a short time before the operations were carried out.1 It is stated2 that morphin and several of its derivatives when given in therapeutic doses will cause no alteration in the respiratory metabolism, while conclusions concerning the protein metabolism are at variance, some observers having found an increase and others a decrease in the intensity. In either case the variation seems to have been quite slight. With atropin and several of its congeners, however, a somewhat more definite result seems to have been obtained. De Stella,3 after long-continued small doses of scopolamin, noted in four experiments on rabbits and dogs that

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