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Article
May 1910

A MODIFIED METHOD FOR THE CLINICAL ESTIMATION OF PEPSIN

Author Affiliations

NEW HAVEN, CONN

From the Sheffield Laboratory of Physiological Chemistry, Yale University.

Arch Intern Med (Chic). 1910;V(5):459-465. doi:10.1001/archinte.1910.00050270013002
Abstract

In the chemical examination of stomach contents attention has lately been directed anew to the estimation of the enzyme content of the gastric secretion, and a number of relatively simple methods of analysis have been proposed. Among these are the methods of Volhard,1 Fuld and Levison,2 Gross,3 and Jacoby and Solms.4 The Jacoby-Solms procedure appears to offer the greatest advantages, and has received favorable consideration for clinical purposes in this country from Goodman5 and Einhorn,6 and abroad from Witte7 and others. The method involves the preparation of an imperfect solution of commercial "ricin" (prepared from the castor bean). This fluid is rendered more turbid by addition of a small amount of acid. Diluted gastric contents are added in varying quantity to a series of test-tubes containing the same volume of the turbid ricin solution; and after the total volumes of fluid are

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