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May 1910

FURTHER STUDIES ON THE INFLUENCE OF THE DUCTLESS GLANDS ON THE PANCREAS

Author Affiliations

PHILADELPHIA

From the Woodward Fellowship of Physiological Chemistry, Pepper Laboratory of Clinical Medicine, and the S. Weir Mitchell Laboratory of Physiology, University of Pennsylvania.

Arch Intern Med (Chic). 1910;V(5):466-481. doi:10.1001/archinte.1910.00050270020003
Abstract

In some recent contributions1 we published the results of investigation, extending over about two years, on pancreatic activity, which led to the following, among other, conclusions:

The suprarenal and pituitary bodies of dogs contain something which, on injection into other dogs, inhibits the flow from the pancreas when excited by secretin. This inhibitory substance can be extracted by salt solution and has been found as yet in no other tissue of the body.

Inhibition occurs whether the extracts be injected before, coincidently with, or after the injection of secretin, and we ventured the tentative view that it was independent of the general blood-pressure.

Our method of recording the flow from the pancreas is by means of a graduated cannula in the duct of Wirsung. As the juice flows past the divisions on the cannula its motion is recorded on the base line of a revolving drum supplied with

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