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The relation of disease of the hypophysis cerebri to certain forms of gigantism and acromegaly has been long known and widely confirmed clinically. We have only begun to realize the wide variety and numerous combinations of symptoms attributable to pathologic conditions of this little body. Its function is still more or less a mystery, and our idea of its histologic structure has only recently been thoroughly defined. Theories of the effect of its internal secretion on general metabolism have been widely divergent. Clinical observations when correlated with pathologic findings have often seemed to lead to contradictory conclusions. The era of experimentally produced and scientifically controlled lesions has just begun. With the accumulation of data from this source and from the sharpened clinical observations, we may expect soon to have an immense light thrown on this most mysterious of all the mysterious ductless glands. With the hope of adding
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