Within the last few years the demand for diagnostic signs that will permit of early diagnosis in all forms of tuberculosis has caused considerable interest in the application of various tuberculin tests. The difficulties in the way of the proper application of the subcutaneous test and its subsequent proper observation, together with its inapplicability in febrile cases, has brought forth various cutaneous tests, the two of most importance being the conjunctival test of Wolff-Eisner and the cutaneous test shortly afterward announced by von Pirquet.
Modern literature on tuberculosis abounds with contributions on this subject. In spite of this, the medical mind is to-day in a state of confusion as to the interpretation of these reactions; and, as a result, they are popularly used as short cuts to diagnosis, the result of reactions is frequently misinterpreted, and an importance attributed to them which leads to the neglect
EVANS GH, WHITNEY JL. A PRELIMINARY REPORT ON THE DIAGNOSTIC VALUE OF THE INTRACUTANEOUS TUBERCULIN TEST. Arch Intern Med (Chic). 1910;VI(3):307-313. doi:10.1001/archinte.1910.00050310078007