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November 1910

THE INDUCTION OF PANCREATIC ACTIVITY BY THE REMOVAL OF THE ADRENALS

Author Affiliations

PHILADELPHIA

From the S. Weir Mitchell Laboratory of Physiology and the Woodward Fellowship, Pepper Laboratory of Clinical Medicine, University of Pennsylvania.

Arch Intern Med (Chic). 1910;VI(5):536-576. doi:10.1001/archinte.1910.00050330071006
Abstract

We reported before the Association of American Physicians in Washington, May, 1909,1 the results of our work on the relation of certain ductless glands to the pancreas, and we there offered among other conclusions, the following:

  1. The inhibition of pancreatic secretion by adrenalin is independent of systemic blood-pressure, as shown by its persistence when the blood-pressure is much below normal and by other evidence.

  2. The inhibition by extracts of pituitary and suprarenal bodies also occurs when the pancreas is stimulated by its normal excitant, hydrochloric acid in the duodenum.

  3. The evidence now at hand indicates that the suprarenal glands exercise an inhibitory power on the pancreas, and that on the removal of this influence by ablation the pancreas secretes more actively.

  4. The agonal period of life (in the sense described) is generally accompanied by an exacerbation of the normal rate of pancreatic

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