July 1911


Author Affiliations


From the Laboratories of Physiological Chemistry of the University of Illinois, and of the Department of Medicine of the University of Pennsylvania.

Arch Intern Med (Chic). 1911;VIII(1):39-57. doi:10.1001/archinte.1911.00060070044003

INTRODUCTION  It has long been recognized that reducing material appears in the urine following the induction of chloroform narcosis in man or the lower animals. At the time the data from the first experiments made by me were reported1 it was not generally known, so far as I am aware, that any considerable glycosuria could be induced in lower animals by subjecting them to ether anesthesia.2Among the earlier investigators of the chloroform glycosuria were Hégar and Kaltenbach.3 They observed that the urine following chloroform anesthesia possessed reducing power and asserted that this reducing power was not due to the production of sugar but to the presence in the urine of chloroform which was excreted in part through the kidneys. A few years later Zweifel4 found that the urine of the fetus had reducing power after the mother had been anesthetized. This investigator main

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