Malignant tumors, primary in the adrenal glands, are of interest to the surgeon and to the pathologist alike. To the surgeon the chief interest centers in the problems of clinical diagnosis and treatment; for the pathologist the comparative rarity of such growths, certain features of their clinical symptoms, and the possible relation of such tumors to malignant hypernephromas of the kidney, combine to make this field one for constant observation and research.
Williams1 out of a series of 8,378 consecutive cases of malignant tumors in some part of the body, found only one which was primary in the adrenals; Matter2 found one case in a series of 3,100 autopsies; Hodge,4 eleven in 6,200 autopsies; Gwilt,5 none in 13,971 autopsies, while Brüchanow,6 at Prague, found in the autopsy records of the Pathological Institute for the years 1884 to 1899, inclusive, but thirty-three primary adrenal tumors,
DAVIS BF. MALIGNANT TUMORS OF THE ADRENAL. Arch Intern Med (Chic). 1911;VIII(1):60-74. doi:10.1001/archinte.1911.00060070065005