In a previous ar ticle,1 I reported the result of treatment with unchanged virus fixe in forty cases. Review of the literature on this subject shows that the ultimate result of the preventive treatment is best when the least changed virus fixe is used.
Regardless of the good results from the exclusive use of unchanged virus fixe obtained by Ferran and myself, no other Pasteur institute has exclusively adopted this method. The aversion to producing experimental rabies by using unchanged virus fixe only, is not yet overcome.
In my first paper I stated that Ferran was of the opinion that one injection would give complete immunity.
In my first series of forty cases the patients were treated with doses fifty times larger than given by Ferran. The first ten patients were given two injections daily, eleven, one injection daily for ten days, and the remaining nineteen were given
PROESCHER F. FURTHER EXPERIENCE IN THE PREVENTIVE TREATMENT OF RABIES WITH UNCHANGED VIRUS FIXE. Arch Intern Med (Chic). 1911;VIII(3):351-355. doi:10.1001/archinte.1911.00060090088003