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Article
September 1911

A CONSIDERATION OF SOME CHEMICAL TRANSFORMATIONS OF PROTEINS AND THEIR POSSIBLE BEARING ON PROBLEMS IN PATHOLOGY

Author Affiliations

NEW HAVEN, CONN.

Arch Intern Med (Chic). 1911;VIII(3):356-381. doi:10.1001/archinte.1911.00060090093004
Abstract

Recent investigations concerning the structure of proteins have led to a readjustment of our ideas with respect to the manner in which these substances may become an integral part of the organism; and the study of the changes which occur from the time when protein has been built up into cell structure until its exit from the body in the form of waste products is at present only in its infancy. According to the newer conception, the protein molecule is a huge complex consisting of the union of a large number of simple amino-acids. This conception is due largely to the researches of Emil Fischer, who has succeeded in fastening together various combinations of amino-acids in such a manner that the resulting compound behaves in some respects like certain of the proteins. Some of these substances, called polypeptids, have indeed been isolated from the decomposition of native protein. According to

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