November 1911


Author Affiliations


From the Russell Sage Institute of Pathology, New York.

Arch Intern Med (Chic). 1911;VIII(5):639-647. doi:10.1001/archinte.1911.00060110085008

Since the time of Vesalius (1514-64) a great profusion of types of liver disease have been described and each associated with a more or less definite train of symptoms, till the present time leaves us with the most confused ideas of the pathological processes at work in almost any case of jaundice. As a result, the diagnosis of cases of long-continued jaundice, exclusive of those due to such obstructive causes as gall-stones, tumor growth, etc., leads inevitably into the tangled artificial classification of the various destructive lesions of the liver.

One fact is certain—that in the whole range of diseases of the liver, from acute yellow atrophy to atrophic cirrhosis, the cases present an extreme variation as regards duration, symptomatology and morbid anatomy; and it may equally be noted that great numbers of cases present features which preclude them from any of the usual subdivisions of liver disease.

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