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Article
December 1911

A COMPARATIVE INVESTIGATION OF THE EFFECTS AND TOXICITY OF SODIUM SALICYLATES OF NATURAL AND SYNTHETIC ORIGIN

Author Affiliations

CHARLOTTESVILLE, VA.

From the Pharmacological Laboratory of the Medical School of Western Reserve University, Cleveland.

Arch Intern Med (Chic). 1911;VIII(6):784-805. doi:10.1001/archinte.1911.00060120070004
Abstract

PART I.—INTRODUCTION BY TORALD SOLLMANN  There is a very prevalent, although not quite universal, belief that salicylates prepared synthetically are less effective, and especially that they are more dangerous and more toxic, than salicylates prepared from the "natural" methyl salicylate, that is, from unadulterated oil of wintergreen or oil of sweet birch. This subject is of great practical importance, on account of the extensive use of salicylic compounds in medicine, and the tendency and often the absolute need of pushing the dosage to the very limit of tolerance. If there is in fact any material difference in the effects, prescribing should certainly be confined exclusively to the less dangerous variety.On the other hand, the difference in cost between the two varieties is very considerable. For instance one of the two synthetic brands used in this investigation is quoted, at wholesale, at 45 cents per pound, while a commercial

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