In a former study1 it was shown that diffuse arterial lesions of a mild grade were frequently associated with certain acute infectious diseases in young people. These lesions were in no way characteristic of acute infections, as they were similar to the usual lesions found in the arteries in old age, whatever be their causes. These lesions consisted of fatty changes with or without cellular invasion in the intima and media of the vessels. In some cases the connective tissue was increased in the intima, media or both, and in some there was loss of muscle substance in the media. In the arteries in the spleen there was a peculiar hyaline-like degeneration involving one or all the coats. It is impossible to say, therefore, whether or not these lesions in these special cases are due to the toxins of the disease.
In one of the cases of
FROTHINGHAM C. ARTERIAL LESIONS FOUND IN PERSONS DYING FROM ACUTE INFECTIONS, AND ATTEMPTS TO PRODUCE ARTERIAL LESIONS IN ANIMALS BY NON-INFECTIOUS TOXINS. Arch Intern Med (Chic). 1912;X(2):103-107. doi:10.1001/archinte.1912.00060200032003