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Article
February 1913

THE EFFECTS OF EXPERIMENTAL CHRONIC PASSIVE CONGESTION ON RENAL FUNCTION

Author Affiliations

BALTIMORE

From the Pharmacological Laboratory of the Johns Hopkins University and the Medical and Genito-Urinary Clinics of the Johns Hopkins Hospital.

Arch Intern Med (Chic). 1913;XI(2):121-147. doi:10.1001/archinte.1913.00060260002001
Abstract

By experimental methods, the production of varying grades of chronic passive congestion of the kidney has been attempted in order to determine its effect on the urinary and clinical findings, on the excretory capacity of the kidney as revealed by certain functional studies and on the histological structure of the kidney.

In every cardiorenal case which he encounters the physician confronts problems which he is called on to solve. Is the heart or kidney chiefly involved in this case ? Which is more responsible for the clinical picture here exhibited? Do permanent and irreparable organic changes exist in the kidneys which preclude the hope of reestablishing a condition of relatively good health, or will the decreased renal function return to normal with the improvement in the cardiovascular system consequent on the enforced confinement to bed? Can chronic passive congestion alone be responsible for the clinical findings? Shall the treatment be directed

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